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Semaglutide
Semaglutide is similar to a natural hormone in your body (incretin). It works by controlling your appetite.
Semaglutide works by activating receptors in the body called GLP-1 receptors, which are mainly found in the pancreas, brain, stomach and other organs. Semaglutide acts like a natural hormone called GLP-1, which helps the body produce more insulin when blood sugar levels are high. This helps to regulate and lower blood sugar levels after eating.
Semaglutide has a strong effect on the parts of the brain that control hunger and feeling full. This means it can make people feel less hungry and more satisfied after eating, which helps them eat less overall. It also slows down how quickly the stomach empties, which further helps control blood sugar levels and supports people in managing their weight in the long term.
- Research dose is taken once a day, every 7 days.
- Start with a research dose at 0.25mg once a week.
- Increasing the research dose by 0.25-0.50mg every 3-4 weeks.
- To not exceed a maximum of 2.4mg.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, gallbladder disease, disease of the pancreas (pancreatitis), a certain eye problem (diabetic retinopathy), mental/mood disorders (such as depression, thoughts of suicide), certain stomach/intestinal disorders (gastroparesis, problems digesting food). If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication(s), exercise program, or diet.
You should not become pregnant while using semaglutide and for 2 months after the last dose. Semaglutide may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this medication passes into breast milk.
If you miss a dose, use it as soon as you remember. If it is less than 48 hours before the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Case Studies:
- Weight Loss in Obese Adults (2021, STEP 1 Trial – NEJM): Participants using Semaglutide lost an average of 14.9% of body weight over 68 weeks, significantly more than placebo. [N Engl J Med. 2021;384:989–1002.]
- Cardiovascular Risk Reduction in Diabetics (2016, SUSTAIN-6 Trial): Semaglutide reduced the risk of major adverse cardiovascular events (MACE) by 26% in patients with type 2 diabetes. [N Engl J Med. 2016;375:1834–1844.]
- Improved Liver Health and Insulin Sensitivity (2020, Lancet Gastroenterol Hepatol): In non-alcoholic fatty liver disease (NAFLD) models, Semaglutide significantly reduced liver inflammation and fat accumulation. [Lancet Gastroenterol Hepatol. 2020;5(4):362–373.]