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TB 500
TB-500 (Thymosin Beta-4 Acetate)
Primary Function: Tissue repair, wound healing, anti-inflammatory modulation
Research Use: Muscle recovery, injury healing, angiogenesis, fibrosis inhibition
Molecular Formula: C212H350N56O78S
CAS Number: 77591-33-4
Synonyms: Thymosin Beta-4 Acetate, Tβ4, TB500
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring peptide found in nearly all human cells. It plays a vital role in tissue regeneration, angiogenesis, cell migration, and inflammation control. TB-500 is widely researched for its ability to accelerate recovery from injury, reduce scar formation, and promote muscle and ligament healing through its action on actin regulation and stem cell recruitment.
- Taken every other day at a research dose of 2-3mg every 3 days or 200-600mcg daily.
- Do not take longer than 12 weeks.
- Recommended research dosing is reactive after injury occurrence.
Mechanism of Action:
- Regulates actin polymerization, aiding cell migration and wound closure
- Stimulates angiogenesis (new blood vessel formation)
- Suppresses pro-inflammatory cytokines like IL-1β and TNF-α
- Enhances stem cell differentiation and mobilization
- Inhibits fibrotic processes and promotes connective tissue remodeling
Key Research Areas:
- Muscle and ligament injury repair
- Wound healing and surgical recovery
- Cardiac ischemia and tissue fibrosis
- Corneal and ocular surface regeneration
- Inflammatory modulation in chronic disorders
History of Discovery:
Thymosin Beta-4 was originally isolated in the 1970s by Dr. Allan Goldstein and colleagues at George Washington University as a major thymic peptide involved in immune regulation and healing. TB-500, the synthetic acetate form, was developed for research use to study regenerative effects in non-immune tissues, with strong early results in both cardiac repair and soft tissue regeneration.
Case Studies:
1. Soft Tissue Repair (2007, Ann N Y Acad Sci): TB-500 improved healing rates in tendon and muscle tissue injuries by over 30% in animal models. [Ann N Y Acad Sci. 2007;1112:129–135.]
2. Cardiac Tissue Recovery (2004, Circulation): Post-MI rodent models showed increased angiogenesis and reduced scarring with TB-500 treatment. [Circulation. 2004;110(4):499–506.]
3. Ocular Surface Healing (2005, Invest Ophthalmol Vis Sci): TB-500 accelerated epithelial healing in dry eye and corneal damage models. [Invest Ophthalmol Vis Sci. 2005;46(1):179–186.]