TB 500
TB 500
TB-500 (Thymosin Beta-4 Acetate)
Primary Function: Tissue repair, wound healing, anti-inflammatory modulation
Research Use: Muscle recovery, injury healing, angiogenesis, fibrosis inhibition
Molecular Formula: C212H350N56O78S
CAS Number: 77591-33-4
Synonyms: Thymosin Beta-4 Acetate, Tβ4, TB500
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring peptide found in nearly all human cells. It plays a vital role in tissue regeneration, angiogenesis, cell migration, and inflammation control. TB-500 is widely researched for its ability to accelerate recovery from injury, reduce scar formation, and promote muscle and ligament healing through its action on actin regulation and stem cell recruitment.
Mechanism of Action:
- Regulates actin polymerization, aiding cell migration and wound closure
- Stimulates angiogenesis (new blood vessel formation)
- Suppresses pro-inflammatory cytokines like IL-1β and TNF-α
- Enhances stem cell differentiation and mobilization
- Inhibits fibrotic processes and promotes connective tissue remodeling
Key Research Areas:
- Muscle and ligament injury repair
- Wound healing and surgical recovery
- Cardiac ischemia and tissue fibrosis
- Corneal and ocular surface regeneration
- Inflammatory modulation in chronic disorders
History of Discovery:
Thymosin Beta-4 was originally isolated in the 1970s by Dr. Allan Goldstein and colleagues at George Washington University as a major thymic peptide involved in immune regulation and healing. TB-500, the synthetic acetate form, was developed for research use to study regenerative effects in non-immune tissues, with strong early results in both cardiac repair and soft tissue regeneration.
Case Studies:
1. Soft Tissue Repair (2007, Ann N Y Acad Sci): TB-500 improved healing rates in tendon and muscle tissue injuries by over 30% in animal models. [Ann N Y Acad Sci. 2007;1112:129–135.]
2. Cardiac Tissue Recovery (2004, Circulation): Post-MI rodent models showed increased angiogenesis and reduced scarring with TB-500 treatment. [Circulation. 2004;110(4):499–506.]
3. Ocular Surface Healing (2005, Invest Ophthalmol Vis Sci): TB-500 accelerated epithelial healing in dry eye and corneal damage models. [Invest Ophthalmol Vis Sci. 2005;46(1):179–186.]
BPC157
(Body Protection Compound-157)
BPC-157 (Body Protection Compound-157)
Primary Function: Tissue regeneration, gut repair, vascular healing
Research Use: Tendon and ligament recovery, intestinal integrity, inflammation modulation
Molecular Formula: C62H98N16O22
CAS Number: 137525-51-0
Synonyms: PL 14736, Pentadecapeptide BPC, Body Protection Compound
Description:
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It is extensively studied for its role in tissue regeneration, angiogenesis, and inflammation control, particularly in musculoskeletal injuries, gut disorders, and vascular dysfunction. BPC-157 has shown powerful effects in accelerating healing in soft tissues like tendons, ligaments, and intestines, while promoting cellular repair and protecting against oxidative damage.
Key Research Areas:
- Tendon and ligament healing
- Inflammatory bowel disease and gut permeability
- Muscle regeneration and post-surgical recovery
- Neurological and vascular protection
History of Discovery:
BPC-157 was first developed by researchers in Zagreb, Croatia in the early 1990s. It was isolated as a fragment of a native gastric peptide involved in protecting and repairing the gastrointestinal tract. Ongoing studies have since uncovered broader applications in systemic tissue repair and neurovascular regeneration.
Case Studies:
- Achilles Tendon Healing (2011, J Orthop Res): Rats treated with BPC-157 showed improved collagen organization and faster recovery of tendon strength. [J Orthop Res. 2011;29(3):437–444.]
- Gastrointestinal Barrier Protection (2009, Curr Pharm Des): BPC-157 prevented NSAID-induced gut injury and maintained epithelial integrity in rodent models. [Curr Pharm Des. 2009;15(7):778–789.]
- Vascular Recovery Post-Trauma (2010, J Physiol Pharmacol): BPC-157 stimulated blood vessel regeneration and reduced clot formation following vascular injury. [J Physiol Pharmacol. 2010;61(5):565–572.]
- Form: Lyophilized powder
- Purity: ≥ 99%
- Storage: Store at -20°C in a dry, dark environment
- For research use only. Not for human or veterinary use.